The Human Papillomavirus (HPV) is currently the most common sexually transmitted disease. It is estimated that its prevalence is increasing and a recent Lancet Global Health article, endorsed by the WHO, warned that 1 in 3 men over 15 years of age may be infected. Most infections are acquired in middle-aged patients, a reflection of sexual habits and acquired immunity. It has been seen that both spontaneous resolution and infection by new types of this virus are common. Transmission is, fundamentally, through sexual contact. The incubation period is typically 1 to 3 months until genital warts appear, although it can be up to 6 months after contact. The majority of patients report the appearance of new sexual partners in their medical history. These lesions can be observed on any mucosa, although the most common are on the glans, the perianal region and even in the mouth (due to oral sex). However, the virus is also capable of remaining dormant within epithelial cells for prolonged periods. Thus, the infection can persist undetected, even for years. Various studies estimate that the rate of subclinical HPV infection can be as high as 40 percent, and this is demonstrated by the identification of positive viral samples when performing DNA analysis of apparently uninfected genital skin. Visible warts are the most common reason for consultation, although they do not cause pain or discomfort. The real danger of this virus is when it settles in the cervix, where it evolves quickly into cancer. In the penis, it can end up with malignant lesions, but, usually, there are other factors such as phimosis, poor hygiene and lack of medical controls, which influence the appearance of this type of tumors. One of the most effective measures to reduce this disease is the vaccine, which was approved by the Food and Drug Administration (FDA) of the United States in 2006. As of 2011, it was included in the Argentine Mandatory Vaccination Schedule and Currently, it is mandatory at 11 years old.